Fig 1: Increased gene expression in Gly-Ser-Thr metabolism axis and decreased gene expression in chemokine signaling pathway as well as inflammatory markers after Taodan granule (TDG) treatment. (A) Expression determined by ELISA: CBS, Sardh, GNMT, Pgam2, and Sdsl in Gly-Ser-Thr axis; Vav1, Lyn, Hck, Prkcb, and CXCL13 in chemokine signaling pathway; IL-17a as well as TNF-a protein in lesions. (B) Representative immunohistochemistry sections of NF-?B nuclear staining (brown) of the back skin lesions (200×). Quantification of NF-?B+ cells in back lesions. Scale bar = 100 µm. The data are expressed as the mean ± SD. Four skin lesions in each group were included for analysis. # p < 0.05, ## p < 0.01, ### p < 0.001, compared with the control group. *p < 0.05, **p < 0.01, ***p < 0.001, compared with the imiquimod (IMQ) group.